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KMID : 0363320100310020201
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Journal of Korean Oriental Internal Medicine
2010 Volume.31 No. 2 p.201 ~ p.211
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Effects of Arctium lappa Linne on the DNFB-induced allergic dermatitis
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Kim Gae-eun
Jung Sung-Ki
Jung Doo-Young
Jang Hyung-jin
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Abstract
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Objectives : Atopic dermatitis is a chronic inflammatory skin disease which is characterized by severe pruritis, erythema, edema, effusion and scabs. The aim of this study was to understand effects of Arctium lappa Linne, which is well known for its efficacy for various skin diseases, on atopic dermatitis
Methods : We conducted this experiment using the DNFB-induced NC/Nga mice. After two weeks of applying DNFB to NC/Nga mice, severe symptoms of atopic dermatitis occurred. We divided the mice into three different groups: a control group which was given no treatment at all, a group treated with dexamethasone (1mg/kg), and another group treated with Arctium lappa Linne (300mg/kg). After one week of treatment, results were recorded according to their improvement on skin, itching behavior, IL-4, and INF- measurement, which is a significant criterion for diagnosing atopic dermatitis.
Results : Itching behavior showed significant improvement in the Arctium lappa Linne group. However Arctium lappa Linne failed to reduce IL-4 and INF- count. Also there was no satisfying improvement on AD-like skin lesions on the rostral back of the NC/Nga mice treated with Arctium lappa Linne.
Conclusions : Arctium lappa Linne showed improvement in itching behavior in NC/Nga mice induced by DNFB. Arctium lappa Linne showed neither significant improvement on skin lesions nor in IL-4 and INF- measurement.
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KEYWORD
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Atopic dermatitis, Arctium lappa Linne, Nc/Nga mice, DNFB
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